Preclinical study data now accessible courtesy of the Critical Path Institute
Data from the PAN-TB Collaboration’s 2020-2023 pharmacokinetic and relapsing mouse model (RMM) studies are now available through the Critical Path Institute Data Archive platform. These preclinical studies evaluated the combination pharmacokinetics and the combination efficacy of novel four-drug combinations of seven priority anti-TB drugs and drug candidates: Bedaquiline (B), Pretomanid (Pa), Sutezolid (Sut), GSK286 (286), GSK830 (830), Delamanid (Del) and Quabodepistat (Q) (formerly OPC-167832 or OPC).
Study data currently available:
- Pharmacokinetic evaluations of novel 4-drug anti-TB drug combinations in mice with multiple dosing frequencies to inform RMM studies, in addition to evaluations of comparator drug combinations
- Relapsing mouse model evaluations of novel 4-drug anti-TB drug combinations
All available data is mapped to the Clinical Data Interchange Standards Consortium (CDISC) Standard for Exchange of Nonclinical Data (SEND).
Researchers can request access to the data by following the link below. All access requests are reviewed by a committee and may take up to four weeks to process. New data will be added as they become available.
PAN-TB Collaboration Announces the Start of a Phase 2 Clinical Trial to Evaluate Two Novel Tuberculosis Treatment Regimens
Public-private partnership launched a first-of-its-kind phase 2b/c trial to evaluate two novel tuberculosis drug regimens with the potential to treat all forms of active pulmonary TB
Phase 2b/c Clinical Trial Update
The Phase 2b/c trial was launched in South Africa in July 2023. Sites in South Africa and the Philippines are actively screening and enrolling participants. As of June 28, 2024, 90 participants have been enrolled.
Overview of Partners
The members of the PAN-TB collaboration have committed to leveraging their unique assets, resources and scientific expertise to advance the development of novel regimens.
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